Since both type 1 and type 2 diabetes have been associated with oxidative stress by researchers, in this article we will discuss how to fight diabetes by reducing oxidative stress. While diabetes is widely considered as one condition, available research has shown that it is indeed a combination of various conditions which cause high levels of blood sugar levels.

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The focus will be on supplementing glutathione, which is the major antioxidant that eliminates toxins and free radicals in the human body, to tackle diabetes. The rationale for this focus is derived from the heightened increase in scientific studies demonstrating the large role played by oxidative stress in the growth and development of both types of diabetes mellitus.

The imbalance experienced between the production of antioxidant defenses and free radicals is termed as oxidative stress. It suggests, therefore, the reduced capability of vital body organs to eliminate toxins presented by free radicals (reactive oxygen species) and a consequent incapacity to repair the damage caused by these free radicals. While short term oxidative stress has been found to significantly reduce aging through mitohormesis, severe oxidative stress reduces the effectiveness of such antioxidant defenses as glutathione whereas the production of free radicals and peroxides tends to increase. Oxidative stress thus contributes to the production of tissue damage in diabetes mellitus.

As the levels of free radicals in the body become too high, the mechanisms of antioxidant defense are bound to decline. This may result in insulin resistance, damage of organelles and enzymes of the body cells and an increase in the peroxidation of lipids. In this way oxidative stress plays a role in the pathogenesis and development of diabetic complications.

Glutathione and Oxidative Stress

As I mentioned earlier, glutathione is the primary antioxidant in the human body. This antioxidant is synthesized endogenously in the entire body and is present in all the cells with varied concentrations. The highest concentrations, however, are found in the liver. Glutathione is considered the primary antioxidant because of the roles it plays in detoxifying electrophilic xenobiotics, regulation of immune responses, deoxyribonucleotide synthesis and antioxidant defense.

As free radicals are generated in excess of the body’s natural ability to clear and neutralize them, the body suffers from oxidative stress. Free radicals are unstable oxygen molecules which can damage DNA and impair the functioning of organs such as the liver. Ideally, atoms share electrons with other atoms to form molecules consisting of stable atoms. Stable atoms are those which have equal pairs of electrons and protons.

Free radicals are formed when a molecule splits leaving an atom with an electron that is unpaired. This unstable atom then attacks other molecules in attempt to take an electron causing a chain reaction of formation of free radicals. This chain reaction disrupts the balance within living cells. Glutathione is therefore responsible for maintaining a balance in the redox state in the body which includes repairing the damage resulting from oxidative stress. Within the cells, glutathione serves to decrease oxidized forms of other antioxidants like alpha-tocopherol and ascorbate. Consequently, glutathione helps to reduce oxidative stress which is a key contributing factor in the development of complications relating to diabetes hence helping in the fight against both types of diabetes.

The Need to Supplement Glutathione

The human body’s capacity to naturally produce glutathione is reduced by 1% every year over the age of 20. Also, most people have a reduced capacity to naturally produce this antioxidant as a result of genetic mutation, modern diets, and a toxin-ridden environment. Glutathione is also attacked directly by free radicals and other oxidative agents. These combined factors lead to an increase in the presence of toxins and free radicals in our bodies. This makes the body unable to produce sufficient glutathione for its protection hence oxidative stress.

Furthermore glutathione in the human body is subjected to strict homeostatic control inside and outside the cells. This is to ensure the maintenance of a complex balance between the synthesis, recycling and utilization of reduced glutathione (GSH) from oxidized glutathione. The recycling of reduced glutathione is catalyzed by glutathione disulfide reductase. Reduced glutathione is conserved by the reducing power of ascorbate. This cycle tries to ensure reduced glutathione is produced as it is used up. Still, the synthesis of glutathione can be slower than its depletion. This has necessitated the supplementation of the natural production capacity of the body.

Glutathione Supplements

Scientists have been able to develop an exogenous form of the primary antioxidant of the body. This product is known as Nano Glutathione and is most useful for individuals experiencing high levels of oxidative stress which greatly reduces metabolism. Nano Glutathione helps the body to maintain its metabolic efficiency by eliminating toxins present in the system and alleviating oxidative stress. While the product does not substantially increase the concentration levels of intracellular glutathione in the body, it has been found to be absorbed very fast into the bloodstream. At least 60% of each 200mg dose of I-glutathione is absorbed about 90 seconds after contact with the mucous membranes. The supplement can be taken at home and does not require IV injections which are as expensive as they are costly. All one needs is a drop of Nano Glutathione under the tongue. This is according to the study of Nano Glutathione permeation.

Other Options

There are other simple ways to promote the body’s production of glutathione. This includes furnishing the body with the nutrients it requires to maintain redo balance hence enhancing the production of glutathione over a long period. These nutrients are present in a variety of foods. Among them are such foods as organically produced fruits and vegetables, turmeric, red meat, meat from organs, raw eggs, whey protein and raw eggs. Maintaining low stress levels and a healthy exercise regimen may also be beneficial in promoting glutathione production. This is because the body’s ability to produce glutathione relies heavily on adenosine triphosphate. Physical activity is important to kick start the body’s energy system.

Glutathione has been shown to provide health benefits and be supportive in relation to a large number of conditions. In order to maintain optimal glutathione levels, consider supplementing with Nano Glutathione.